I’m testing if it’s UEFI vs Legacy and so far it’s looking good! (got F41 installed to CFL in Legacy boot with SD card having /boot and NVMe all /; Anaconda’s pretty good 
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Toggled the usual BIOS settings, Wayland, and Xorg, and all reboots and log-ins worked.
Edit: Couple days on F41 (Workstation/GNOME, Wayland, no auto-login) with over a dozen reboots had no issue, and I changed the 3 suspect BIOS settings (C-States/HT/SpeedShift) and rebooted no problem. I’m thinking Legacy boot is the key!