Was messing with this more last night and wrote some notes: https://wiki.realmofespionage.xyz/linux:notes:wine_wayland_vulkan_wow_335
But it seems to work pretty well! WoW doesn’t show up under Xwayland for GPU usage or any X detection apps, and it can run in Wine with both vulkan renderer and wayland display with DXVK installed to the prefix and WoW in d3d9ex mode.
With Software cursor (disabled HW cursor in-game) it feels better vulkan/wayland vs default gl/x11! I think this would be most-noticeable on F41/GNOME 47+.
There’s some rendering stuff that prevented both vulkan/wayland from working in some situations (iirc OpenGL with WoW with Wine wayland and Wine vulkan only working in WoW d3d9 with DXVK installed and not WineD3D/default-GL-wrapper), so it seems mostly trial-and-error for now.