Sorry, this is not a good fit for Common Issues , moving to Ask Fedora with a howto tag. This is very likely hardware-specific, the reporter is affected only when using a custom pipewire script to reverse audio, and there’s no indication that this would affect a large portion of Fedora users. It’s definitely not a universal issue (audio in my wine/proton games is completely fine). Affected users can find this using search in Ask Fedora.
I removed the HowTo tag due in part to your statement, which I agree with and the scope of the post.
A potential hardware issue, with a work around yet we do not know what hardware is utilized here.
This work around, might solve the OP’s problem, but I have extensively tested games on several builds/configurations from Proton3.x/GE/tkg, Lutris also during the inception of Pipewire and not had such issues.
Users experiencing issues to this degree should reach out through a forum thread with full hardware specs and begin troubleshooting from there.