VBox guest - dead after latest update

[computersavvy (Jeff V)]

This may be related to the common issue here since the kernel module for VirtualBox is a 3rd party module.

Third-party modules (e.g. Nvidia) are not rebuilt during system upgrade

Problem If you use a third-party kernel module (the most common is the Nvidia closed driver, but this might also apply to some wireless card drivers, VirtualBox, etc), it won’t be rebuilt during a system upgrade to a newer Fedora version. That means your kernel module (and the affected hardware) might not work directly after the system upgrade. In case of Nvidia, that might mean using a slow fallback graphical driver, or even failing to boot to a graphical environment at all. Note: This proble…

If it is then following the steps in the workaround there should fix it.
The package name to remove would be kmod-VirtualBox-6.6.8-200.fc39.x86_64 if you are using the 6.6.8 kernel, or replace the kernel version with whatever kernel you are actually running. Then rebuild that module with the sudo akmods --force as shown in the workaround and VB should be back to functional after a reboot.