Hello.
Yes, sometimes, setting things up is a challenge, however, things are improving.
The QT environment variables are definitely not needed for QT 6, and likely 5. Same can be said about GTK_MODULES, which are not needed at least from GTK 3. GNOME_ACCESSIBILITY, when researching it, is also something from the GNOME 2 days or might be earlier. And ACCESSIBILITY_ENABLED will not be needed for Chromium a11y, but yes, this one might stick a while longer, because of all the Electron apps.