I have been using systemd-homed on fedora Silverblue since v32. This policy was created and built on and for Silverblue. Being adjusted to work on all other spins.
On Atomic versions, you would have to overlayer the rpm package for it to work. ATM, I am rewriting the policy to submit it to the fedora-selinux policy to avoid a separate package to function normally.
Follow the first post on how to set up your new home. Skip steps 1-4, if your using an Atomic desktop and want to use my rpm package below.