Would it be safe to uninstall only Firefox, Games, Educational, Office, most PIM, and Multimedia apps in Fedora KDE?

Ask Fedora
,
1

I’ll only keep Gwenview, Kamoso, and K3b for Multimedia. Akregator is the only PIM app I’m certain I’ll use.

2

Short answer - Probably. Depends on what depends upon the files that those packages provide.

Long answer - Why don’t you try it and see what works (or doesn’t) that you require?

3

If your goal is to strip out unused software also check what services are running.
For example do you need akonadi the service that supports kde pim apps?