I’m running Fedora Workstation 40 and Gnome 46 currently but I noticed the same issue when I tried 41 early as well with Gnome 47. Both using Wayland. Using a 7800X3D and a 7900 XTX.
I’ve been gaming on a 4K OLED TV with a 1440p monitor to my right. I usually have my scaling set to 200% for the 4K TV with 100% on the 1440p monitor. Whenever I’m playing a Wine/Proton game using the mouse, once I go about halfway to the right on the TV with the cursor, the game loses the mouse and it goes to my 1440p monitor on the right instead. I can then go back to the left from my monitor back to the TV, but the cursor seems to instantly appear at about the halfway point on the TV as if the scaling makes it so the mouse can only be used on half of the TV before it moves to the monitor on the right.
I have to close the game and change my scaling in Gnome for the 4K TV back to 100% so I don’t get this issue any more. I’m not sure if Gamescope could help as I haven’t tried, but I’d rather not always have to use it to work around this issue. Is this a known bug? Is there a way to fix this?
Edit: I just tested it again, and for the first time the issue happened even when I set scaling back to 100%, so now I’m not really sure what the problem is.