Is Silverblue + cuda + cudnn + tensorrt + Tensorflow 2.14 and 2.15 + keras possible?

I really like the philosophy and stability of atomic distros, and would like to move my machine learning setup to Silverblue.
Is it possible to do this with minimal agony?
I’ve tried in the past on other distros using distrobox, but always wound up in compatibility hell where the host kernel wasn’t correct for GCC in the container, etc.
I’ve been perusing rpmfusion, fedora discussions, fedorainfracloud, NVCT, etc. and it’s pretty bewildering.

Anyone actually doing this?

For anything NVIDIA related I currently recommend looking at Universal Blue images: