I found the following previous topics:
- Building a new home with systemd-homed on fedora
- Getting systemd-homed working properly on Fedora Workstation
- Enabling systemd-homed managed user&home dir during Fedora install
The first step is probably to document how to enable/use systemd-homed in Fedora and report/fix the remaining issues.
Docs that might help:
Enabling it in Kinoite is kind of enabling it in Fedora as we use the same installer, etc.