There are several graphical interfaces to local encryption tools that you can run on Fedora. I’m aware of one that’s a part of Fedora; the other two here are from Flathub. I’m listing them in order of user friendliness (once they’re installed).
Additionally, there’s a different app frontend called sirikali available directly in Fedora (and it supports encfs, cryfs, gocryptfs, and securefs). The UI is a bit less friendly, however.
Also, if you’re interested in backing things up in an encrypted manner (for external drives and/or remote storage), I’m a huge fan of Pika, which uses borg backup in the background. Vorta is also great. vorta and borgbackup are both available directly in the Fedora repos too.
Both Pika and Vorta from Flathub give you everything you need to start using them, so you don’t have to install anything as an overlay.