Since updating to Fedora 45, apps running with xwayland (e.g. Steam) do not receive mouse input. They do receive keyboard input though.
Mouse clicks go “through” the apps, for example right clicking anywhere on the Steam window shows the Change background… etc. popup.
Tried disabling my extensions, that did nothing, as I expected.
Didn’t find anything on the gnome issues board or fedora bugzilla on this.
Anything running on wayland works fine.