Fedora 40 kernel panics on updates > 6.10.8

VFS: Unable to mount root fs on unknown-block(0,0). usually means there is a problem with the grub configuration, so you should check (use Gnome Disks if you aren’t familiar with command-line tools) for duplicated UUID’s. The installer uses UUID’s to identify partitions, so the grub configuration should be OK unless you made manual changes after installing. One issue is that some systems unexpectedly swap sda and sdb.

We need more details to understand your problem, but there are some things you can try that may resolve the issue

  1. make sure that all updates have been applied, including vendor firmware. Newer kernels may fail when there are “unpatched” security issues in firmware. Fedora has fwupd for vendor firmware, with command-line tools fwupdtool and fwupdmgr, or many vendors support firmware updates using a Windows GUI tool.

  2. try booting 610.10 after using the grub menu editor to remove rhgb quiet from the kernel command-line or by editing /etc/default/grub, then running sudo grub2-mkconfig -o /boot/grub2/grub.cfg to “permanently” remove those options. You will immediately see error messages that are hidden by the default configuration which I think is designed more for mass deployments than for individual users. The error message is often enough to allow you find a solution with searches in this forum or a wider web search (but be very careful of clickbait sites promising “easy” solutions).

  3. hardware tests: some vendors provide tests that can be run at boot time or by booting a USB stick they provide. Gnome Disks can be used to run S.MA.R.T tests.

If you are still having the problem, please provide: hardware and software details:

  1. inxi -Fzxx provides a useful overview but often needs followup questions. inxi is not installed by default, but you can install it in 6.10.8. Please past the output as pre-formatted text (use the </> button from the top line of the text entry panel).
  2. details of the disk layout from lsblk -o +UUID (as pre-formatted text).