Hi Syaifur, I just tried both the install methods you mentioned: the Epson supplied package and the re-bundled RPM Fedora supplies. Both installed into a fresh VM and neither the issues I saw previously occur. Absolutely no idea what went wrong before 
. So it looks like I have several install methods to try when I my hands on the actual printer. Very cool!! Thank you so much for your help with this.
for the record:
1] Using the Eposon supplied binary. Inside a vm this worked well and I can confirm what you saw - there were no effects on the system.
rpm-ostree install epson-inkjet-printer-escpr2-1.1.46-1lsb3.2.x86_64
Deployments:
● fedora:fedora/35/x86_64/silverblue
Version: 35.20220201.0 (2022-02-01T00:47:44Z)
BaseCommit: b9cb7a4311962b34573eb5fea91538647f908a53f63df47ad8e8a3de6c4130cf
GPGSignature: Valid signature by 787EA6AE1147EEE56C40B30CDB4639719867C58F
LocalPackages: epson-inkjet-printer-escpr2-1.1.46-1lsb3.2.x86_64
2] Using the Fedora package, which until you mentioned it was completely unaware of.
rpm-ostree install epson-inkjet-printer-escpr2
Staging deployment… done
Added:
epson-inkjet-printer-escpr-1:1.7.10-2.1lsb3.2.fc35.x86_64
epson-inkjet-printer-escpr2-1.1.24-3.1lsb3.2.fc35.noarch
Deployments:
● fedora:fedora/35/x86_64/silverblue
Version: 35.20220201.0 (2022-02-01T00:47:44Z)
BaseCommit: b9cb7a4311962b34573eb5fea91538647f908a53f63df47ad8e8a3de6c4130cf
GPGSignature: Valid signature by 787EA6AE1147EEE56C40B30CDB4639719867C58F
LayeredPackages: epson-inkjet-printer-escpr2