Disable libvirt and qemu related services

How can I prevent them from loading at startup?
Will it break the system?
Can someone provide a full list of related services, I guess masking should be enough

Disable or mask those services:
Tree - rpms/fedora-release - src.fedoraproject.org

As an alternative, you can simply remove the related packages and their unused dependencies:

sudo dnf remove libvirt\* qemu\*

This way you can reclaim about 400 MB of space and speed up future updates on average.

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I’ll gladly remove them all if it’s easy to reinstall and run them again without pain

If you ever need it, just install gnome-boxes or virt-manager and reboot.
That should automatically pull and start the necessary dependencies.