Just started using it last night on fedora/31/x84_64/silverblue, and I’m not running into any issues. There is one thing I found to keep in mind:
If you have changed your login shell, change it back to the default before upgrading. I uninstalled my overlayed packages before upgrading after and abundance of caution, and found that my main account was detected as a system account.
There’s an easy fix if you end up in this scenario: edit /var/lib/AccountsService/users/$USERNAME, where $USERNAME is replaced by your username